Dr Brian Caffrey

Biography

I am currently working in collaboration with the Rosalind Franklin Institute and the University of East Anglia to develop novel imaging approaches that combine liquid-phase and conventional cryo-electron microscopy, spectroscopy, and correlative light microscopy to investigate biological processes in situ.

My current research focuses on applying these complementary structural and cellular imaging methods to understand mechanisms of antimicrobial resistance and support the development of next-generation antimicrobial therapies. In particular, I am interested in Pseudomonas aeruginosa, an ESKAPE pathogen that is a major cause of chronic infections in patients with cystic fibrosis, and in using advanced structural biology techniques to inform the design and improvement of antimicrobial interventions.