Dr Conrad Nieduszynski

Biography

I am a genome biologist interested in how DNA replication shapes genome stability and evolution. My group combines cutting-edge genomic technologies with systems-level modelling and synthetic genomes to identify the mechanisms that regulate DNA replication across bacteria, archaea and eukaryotes.

I obtained my PhD in biochemistry from the University of Cambridge, where my work included whole-genome analysis of the genes controlling animal cell division. As a postdoctoral researcher at the Universities of Dundee and Aberdeen I used comparative genomics to identify DNA replication initiation sites. A Leverhulme Trust Early Career Fellowship and a BBSRC David Phillips Fellowship (2008) allowed me to establish my own group, first at the University of Nottingham and then at the University of Oxford, and in 2016 I was awarded a Wellcome Investigator Award. I joined the Earlham Institute as a Group Leader in 2020, and my group has been continuously funded by the BBSRC since 2008.

My group has pioneered genomic, computational and systems-biology approaches to quantitatively measure how genomes replicate, both in cell populations and on single molecules. Highlights include developing the first single-molecule sequencing method for studying genome replication, discovering that at least one organism can grow rapidly without replication origins, uncovering mechanisms that ensure stable chromosome inheritance, and showing how synthetic chromosomes can be designed to replicate stably.

Earlham Institute profile: https://www.earlham.ac.uk/profile/conrad-nieduszynski
Bluesky: @conradn.bsky.social
ORCID: https://orcid.org/0000-0003-2001-076X
Google Scholar: https://scholar.google.com/citations?user=ES4F7q0AAAAJ